SLK Mediates apoptosis and actin stress fiber dissolution. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); SLK subfamily; STE group; STE20 family
Chromosomal Location of Human Ortholog: 19|19 C3-D1
Cellular Component:  cell leading edge; cytoplasm; perinuclear region of cytoplasm
Molecular Function:  ATP binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; apoptotic process; cytoplasmic microtubule organization; phosphorylation; positive regulation of apoptotic process; positive regulation of histone phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of apoptotic process; regulation of cell migration; regulation of focal adhesion assembly; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  O54988 (UniProtKB)
Alt. Names/Synonyms: 9A2; AV021402; AW411554; Etk4; Kiaa0204; mKIAA0204; mSLK; Serine/threonine-protein kinase 2; Slk; SMAK; STE20-like kinase; STE20-like kinase (yeast); STE20-like serine/threonine-protein kinase; STE20-related kinase; STE20-related kinase SMAK; STE20-related serine/threonine-protein kinase; Stk2
Gene Symbols: Slk
Molecular weight: 141,457 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
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SLK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene