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IkB-alpha
a regulatory protein that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. Belongs to the NF-kappa-B inhibitor family. Note: This description may include information from UniProtKB. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Inhibitor |
| Chromosomal Location of human Ortholog: 14q13.2 |
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Cellular Component:
cytoplasm; cytosol; I-kappaB/NF-kappaB complex; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
enzyme binding; identical protein binding; molecular sequestering activity; NF-kappaB binding; nuclear localization sequence binding; protein binding; protein sequestering activity; ubiquitin protein ligase binding
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Biological Process:
apoptotic process; B cell receptor signaling pathway; cellular response to cold; cellular response to tumor necrosis factor; cytoplasmic sequestering of NF-kappaB; cytoplasmic sequestering of transcription factor; I-kappaB kinase/NF-kappaB signaling; lipopolysaccharide-mediated signaling pathway; negative regulation of DNA binding; negative regulation of lipid storage; negative regulation of macrophage derived foam cell differentiation; negative regulation of myeloid cell differentiation; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; NIK/NF-kappaB signaling; Notch signaling pathway; nucleotide-binding oligomerization domain containing 1 signaling pathway; nucleotide-binding oligomerization domain containing 2 signaling pathway; positive regulation of cholesterol efflux; positive regulation of inflammatory response; positive regulation of protein metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein import into nucleus; regulation of cell population proliferation; regulation of NIK/NF-kappaB signaling; response to exogenous dsRNA; response to muramyl dipeptide; response to muscle stretch; toll-like receptor 4 signaling pathway; tumor necrosis factor-mediated signaling pathway
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Disease: Ectodermal Dysplasia, Anhidrotic, With T-cell Immunodeficiency, Autosomal Dominant
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Reference #:
P25963
(UniProtKB)
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Alt. Names/Synonyms: EDAID2; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; MAD-3; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; NFKBIA; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
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Gene Symbols: NFKBIA
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Molecular weight:
35,609 Da
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Basal Isoelectric point:
4.57
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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B Cell Receptor Signaling
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Death Receptor Signaling
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Growth And Differentiation Control by MAPKs
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Inhibition of Apoptosis
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NF-kB Signaling
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T Cell Receptor Signaling
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Toll-Like Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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