skMLCK Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.18; Kinase, protein; MLCK family; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2|2 H1
Cellular Component:  cytoplasm; dendrite; dendritic spine; neuronal cell body; nucleus; postsynaptic density; synaptic vesicle; terminal bouton
Molecular Function:  ATP binding; calmodulin binding; kinase activity; myosin light chain binding; myosin light chain kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cardiac muscle cell differentiation; cardiac muscle tissue morphogenesis; neuromuscular synaptic transmission; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of fast-twitch skeletal muscle fiber contraction; positive regulation of gene expression; protein autophosphorylation; protein phosphorylation; regulation of cell cycle; regulation of MAPK cascade; regulation of muscle contraction; regulation of muscle filament sliding; regulation of neuronal synaptic plasticity; skeletal muscle cell differentiation; skeletal muscle satellite cell differentiation; striated muscle contraction; synaptic vesicle transport; water transport
Reference #:  Q8VCR8 (UniProtKB)
Alt. Names/Synonyms: 9830004H17Rik; BB138278; MLCK2; Mylk2; Myosin light chain kinase 2, skeletal/cardiac muscle; myosin, light polypeptide kinase 2, skeletal muscle; skMLCK
Gene Symbols: Mylk2
Molecular weight: 65,990 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

skMLCK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene