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skMLCK
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.18; Kinase, protein; MLCK family; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 2|2 H1 |
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Cellular Component:
cytoplasm; dendrite; dendritic spine; neuronal cell body; nucleus; synapse; synaptic vesicle; terminal bouton
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Molecular Function:
ATP binding; calmodulin binding; kinase activity; myosin light chain binding; myosin light chain kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cardiac muscle cell differentiation; cardiac muscle tissue morphogenesis; neuromuscular synaptic transmission; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of fast-twitch skeletal muscle fiber contraction; positive regulation of gene expression; protein autophosphorylation; protein phosphorylation; regulation of MAPK cascade; regulation of muscle filament sliding; regulation of neuronal synaptic plasticity; skeletal muscle cell differentiation; skeletal muscle satellite cell differentiation; striated muscle contraction; synaptic vesicle transport; water transport
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Reference #:
Q8VCR8
(UniProtKB)
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Alt. Names/Synonyms: 9830004H17Rik; BB138278; MLCK2; Mylk2; Myosin light chain kinase 2, skeletal/cardiac muscle; myosin, light polypeptide kinase 2, skeletal muscle; skMLCK
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Gene Symbols: Mylk2
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Molecular weight:
65,990 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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