VRK2 Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CK1 group; EC; Kinase, protein; Membrane protein, integral; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); VRK family
Chromosomal Location of Human Ortholog: 11|11 A3.3
Cellular Component:  cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane; mitochondrial membrane; mitochondrion; nucleus; protein-containing complex
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular response to oxidative stress; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of interleukin-1-mediated signaling pathway; regulation of MAPK cascade
Reference #:  Q8BN21 (UniProtKB)
Alt. Names/Synonyms: 2810003O05Rik; AI447698; OTTMUSP00000008449; Serine/threonine-protein kinase VRK2; vaccinia related kinase 2; vaccinia virus BIR kinase related kinase 2; Vaccinia-related kinase 2; Vrk2
Gene Symbols: Vrk2
Molecular weight: 58,119 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene