RHBDF1 Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Belongs to the peptidase S54 family. Highly expressed in cerebellum, cerebrum, heart, skeletal muscle, placenta, pancreatic islet and testis. Detected at lower levels in colon, kidney, small intestine and lung. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of mouse Ortholog: 11 A4|11 18.83 cM
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; membrane
Molecular Function:  serine-type endopeptidase activity
Biological Process:  cell migration; cell population proliferation; negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; regulation of proteasomal protein catabolic process; regulation of protein secretion
Reference #:  Q6PIX5 (UniProtKB)
Alt. Names/Synonyms: C16ORF8; Dis; Dist; Dist1; Egfr; Egfr-rs; epidermal growth factor receptor related sequence; Epidermal growth factor receptor-related protein; Inactive rhomboid protein 1; Irhom1; Kiaa4242; mKIAA4242; OTTMUSP00000005544; Rhbdf1; RHDF1; rhomboid 5 homolog 1; rhomboid family 1; rhomboid family 1 (Drosophila); Rhomboid family member 1
Gene Symbols: Rhbdf1
Molecular weight: 97,292 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene