DOCK7 Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3. Belongs to the DOCK family. Widely expressed. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, misc.
Chromosomal Location of Human Ortholog: 4 C6|4 45.6 cM
Cellular Component:  cell projection
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding; Rac GTPase binding
Biological Process:  activation of GTPase activity; axonogenesis; cell differentiation; establishment of neuroblast polarity; hematopoietic progenitor cell differentiation; interkinetic nuclear migration; microtubule cytoskeleton organization; multicellular organism development; negative regulation of cold-induced thermogenesis; nervous system development; neuron projection development; pigmentation; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular associated smooth muscle cell migration; regulation of neurogenesis; small GTPase mediated signal transduction
Reference #:  Q8R1A4 (UniProtKB)
Alt. Names/Synonyms: 3110056M06Rik; dedicator of cytokinesis 7; Dedicator of cytokinesis protein 7; Dock7; Gm430; Kiaa1771; m; mKIAA1771
Gene Symbols: Dock7
Molecular weight: 241,438 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene