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HSP27
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Belongs to the small heat shock protein (HSP20) family. Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. Note: This description may include information from UniProtKB.
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| Protein type: Chaperone; Heat shock protein; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 7q11.23 |
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Cellular Component:
axon cytoplasm; cytoplasm; cytoskeleton; cytosol; nucleus; plasma membrane; proteasome complex; spindle; Z disc
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Molecular Function:
identical protein binding; protein binding; protein binding involved in protein folding; protein homodimerization activity; protein kinase binding; protein kinase C binding; protein kinase C inhibitor activity; ubiquitin binding
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Biological Process:
anterograde axonal protein transport; cellular response to vascular endothelial growth factor stimulus; chaperone-mediated protein folding; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of tumor necrosis factor biosynthetic process; regulation of autophagy; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of mRNA stability; regulation of protein phosphorylation; regulation of translational initiation; response to unfolded protein; response to virus
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Disease: Charcot-marie-tooth Disease, Axonal, Type 2f; Neuronopathy, Distal Hereditary Motor, Type Iib
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Reference #:
P04792
(UniProtKB)
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Alt. Names/Synonyms: 28 kDa heat shock protein; CMT2F; DKFZp586P1322; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein beta-1; HMN2B; HS.76067; HSP 27; Hsp25; HSP27; HSP28; HSPB1; SRP27; Stress-responsive protein 27
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Gene Symbols: HSPB1
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Molecular weight:
22,783 Da
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Basal Isoelectric point:
5.98
Predict pI for various phosphorylation states
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CST Pathways:
Inhibition of Apoptosis
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Regulation of P38 MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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