SGCD Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F). LGMD2F is an autosomal recessive disorder. Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the sarcoglycan beta/delta/gamma/zeta family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Dystrophin complex; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11|11 B1.1
Cellular Component:  cytoplasm; cytoskeleton; dystroglycan complex; dystrophin-associated glycoprotein complex; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; sarcoglycan complex; sarcolemma; sarcoplasmic reticulum
Molecular Function:  protein binding
Biological Process:  calcium ion homeostasis; calcium-mediated signaling; cardiac muscle cell contraction; cardiac muscle contraction; cardiac muscle fiber development; cardiac muscle tissue development; cell death; cellular protein-containing complex localization; coronary vasculature morphogenesis; heart contraction; heart process; membrane organization
Reference #:  P82347 (UniProtKB)
Alt. Names/Synonyms: 35 kDa dystrophin-associated glycoprotein; 35DAG; 35kDa; Delta-sarcoglycan; Delta-SG; OTTMUSP00000005662; RP23-43C21.1; sarcoglycan, delta (35kD dystrophin-associated glycoprotein); sarcoglycan, delta (dystrophin-associated glycoprotein); SG-delta; Sgcd
Gene Symbols: Sgcd
Molecular weight: 32,133 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
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SGCD

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene