SGCD Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Belongs to the sarcoglycan beta/delta/gamma/zeta family. Most strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Dystrophin complex; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 11|11 B1.1
Cellular Component:  cytoplasm; cytoskeleton; dystroglycan complex; dystrophin-associated glycoprotein complex; membrane; plasma membrane; sarcoglycan complex; sarcolemma; sarcoplasmic reticulum
Molecular Function:  protein binding
Biological Process:  calcium ion homeostasis; calcium-mediated signaling; cardiac muscle cell contraction; cardiac muscle cell development; cardiac muscle contraction; cardiac muscle tissue development; coronary vasculature morphogenesis; heart contraction; heart process; membrane organization; protein-containing complex localization
Reference #:  P82347 (UniProtKB)
Alt. Names/Synonyms: 35 kDa dystrophin-associated glycoprotein; 35DAG; 35kDa; A530047J11; A530047J11Rik; AI504364; AW547581; delta; Delta-sarcoglycan; Delta-SG; OTTMUSP00000005662; RP23-43C21.1; sarcoglycan, delta (35kD dystrophin-associated glycoprotein); sarcoglycan, delta (dystrophin-associated glycoprotein); SG-delta; Sgcd
Gene Symbols: Sgcd
Molecular weight: 32,133 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein