ATAD2 May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. Belongs to the AAA ATPase family. Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); EC; Hydrolase
Chromosomal Location of Human Ortholog: 15|15 D1
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  ATP binding; ATPase activity; chromatin binding; histone binding; hydrolase activity; nucleotide binding; protein binding
Biological Process:  chromatin organization; negative regulation of chromatin silencing; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated
Reference #:  Q8CDM1 (UniProtKB)
Alt. Names/Synonyms: 2610509G12Rik; Atad2; ATPase family AAA domain-containing protein 2; ATPase family, AAA domain containing 2; CT137; MGC38189
Gene Symbols: Atad2
Molecular weight: 117,943 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene