DCAMKL2 Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Expressed in the brain, heart and eyes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; DCAMKL family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 3|3 F1
Cellular Component:  cytoplasm; cytoskeleton
Molecular Function:  ATP binding; kinase activity; microtubule binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  hippocampus development; intracellular signal transduction; microtubule cytoskeleton organization; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; phosphorylation; protein localization to nucleus; protein phosphorylation; pyramidal neuron development
Reference #:  Q6PGN3 (UniProtKB)
Alt. Names/Synonyms: 6330415M09Rik; AU044875; CaMK-like CREB regulatory kinase 2; CL2; Clic; CLICK-II; CLICK2; Dcamk; Dcamkl2; Dclk2; doublecortin and CaM kinase-like 2; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; Serine/threonine-protein kinase DCLK2
Gene Symbols: Dclk2
Molecular weight: 82,979 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene