AFAP1L2 May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation
Chromosomal Location of mouse Ortholog: 19|19 D2
Cellular Component:  cytoplasm; cytosol; plasma membrane
Molecular Function:  protein binding; protein tyrosine kinase activator activity; SH2 domain binding; SH3 domain binding; signaling adaptor activity
Biological Process:  inflammatory response; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of transcription, DNA-templated; regulation of interleukin-6 production; regulation of mitotic cell cycle; regulation of signal transduction
Reference #:  Q5DTU0 (UniProtKB)
Alt. Names/Synonyms: actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AF1L2; AFAP1-like protein 2; Afap1l2; AU041783; C86904; Kiaa1914; MGC28084; mKIAA1914
Gene Symbols: Afap1l2
Molecular weight: 92,175 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene