hnRNP K One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 9q21.32
Cellular Component:  catalytic step 2 spliceosome; cell projection; cytoplasm; cytoplasmic stress granule; nuclear chromatin; nucleoplasm; nucleus; podosome
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding; protein binding; protein domain specific binding; RNA polymerase II proximal promoter sequence-specific DNA binding; single-stranded DNA binding
Biological Process:  mRNA splicing, via spliceosome; negative regulation of apoptotic process; negative regulation of mRNA splicing, via spliceosome; positive regulation of low-density lipoprotein particle receptor biosynthetic process; positive regulation of receptor-mediated endocytosis; positive regulation of transcription by RNA polymerase II; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; regulation of low-density lipoprotein particle clearance; RNA metabolic process; RNA processing; signal transduction; viral process
Disease: Au-kline Syndrome
Reference #:  P61978 (UniProtKB)
Alt. Names/Synonyms: CSBP; dC-stretch binding protein; FLJ41122; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; HNRNPK; HNRPK; Transformation up-regulated nuclear protein; transformation upregulated nuclear protein; TUNP
Gene Symbols: HNRNPK
Molecular weight: 50,976 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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