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hnRNP K
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of human Ortholog: 9q21.32 |
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Cellular Component:
catalytic step 2 spliceosome; cell projection; chromatin; cytoplasm; cytoplasmic stress granule; nucleoplasm; nucleus; podosome; ribonucleoprotein complex
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Molecular Function:
DNA binding; identical protein binding; mRNA binding; protein binding; protein domain specific binding
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Biological Process:
mRNA splicing, via spliceosome; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; negative regulation of mRNA splicing, via spliceosome; positive regulation of low-density lipoprotein receptor activity; positive regulation of receptor-mediated endocytosis; positive regulation of transcription by RNA polymerase II; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; regulation of low-density lipoprotein particle clearance; regulation of mRNA splicing, via spliceosome; regulation of transcription by RNA polymerase II; RNA processing; signal transduction
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Disease: Au-kline Syndrome
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Reference #:
P61978
(UniProtKB)
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Alt. Names/Synonyms: AUKS; CSBP; dC-stretch binding protein; FLJ41122; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; HNRNPK; HNRPK; Transformation up-regulated nuclear protein; transformation upregulated nuclear protein; TUNP
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Gene Symbols: HNRNPK
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Molecular weight:
50,976 Da
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Basal Isoelectric point:
5.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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