ZCCHC8 Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. May be involved in pre-mRNA splicing. Belongs to the ZCCHC8 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Spliceosome
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  catalytic step 2 spliceosome; nuclear body; nucleoplasm; nucleus; spliceosomal complex; TRAMP complex
Molecular Function:  metal ion binding; nucleic acid binding; zinc ion binding
Biological Process:  mRNA processing; RNA splicing
Reference #:  Q9CYA6 (UniProtKB)
Alt. Names/Synonyms: 5730565F05Rik; TRAMP-like complex RNA-binding factor ZCCHC8; Zcchc8; ZCHC8; Zinc finger CCHC domain-containing protein 8; zinc finger, CCHC domain containing 8
Gene Symbols: Zcchc8
Molecular weight: 78,026 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
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ZCCHC8

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene