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ZCCHC8
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. May be involved in pre-mRNA splicing. Belongs to the ZCCHC8 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Spliceosome |
| Chromosomal Location of Human Ortholog: 5|5 F |
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Cellular Component:
catalytic step 2 spliceosome; nuclear body; nucleoplasm; nucleus; spliceosomal complex; TRAMP complex
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Molecular Function:
metal ion binding; nucleic acid binding; zinc ion binding
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Biological Process:
mRNA processing; RNA splicing
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Reference #:
Q9CYA6
(UniProtKB)
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Alt. Names/Synonyms: 5730565F05Rik; TRAMP-like complex RNA-binding factor ZCCHC8; Zcchc8; ZCHC8; Zinc finger CCHC domain-containing protein 8; zinc finger, CCHC domain containing 8
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Gene Symbols: Zcchc8
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Molecular weight:
78,026 Da
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Basal Isoelectric point:
4.66
Predict pI for various phosphorylation states
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