SKA3 Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Belongs to the SKA3 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 14|14 C3
Cellular Component:  chromosome; chromosome, centromeric region; condensed chromosome outer kinetochore; cytoplasm; cytoskeleton; kinetochore; microtubule; spindle microtubule
Biological Process:  cell cycle; cell division; chromosome segregation; mitotic cell cycle; regulation of microtubule polymerization or depolymerization
Reference #:  Q8C263 (UniProtKB)
Alt. Names/Synonyms: F630043A04Rik; Rama1; RIKEN cDNA F630043A04 gene; Ska3; spindle and kinetochore associated complex subunit 3; Spindle and kinetochore-associated protein 3
Gene Symbols: Ska3
Molecular weight: 45,370 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
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SKA3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene