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FOG1
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. Belongs to the FOG (Friend of GATA) family. Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; Transcription regulation |
| Chromosomal Location of mouse Ortholog: 8|8 E1 |
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Cellular Component:
nucleus; transcription regulator complex; transcription repressor complex
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Molecular Function:
DNA binding; metal ion binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription corepressor activity
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Biological Process:
atrial septum morphogenesis; atrioventricular valve morphogenesis; cardiac muscle tissue morphogenesis; definitive erythrocyte differentiation; embryonic hemopoiesis; erythrocyte differentiation; granulocyte differentiation; heart development; homeostasis of number of cells; megakaryocyte development; megakaryocyte differentiation; mitral valve formation; negative regulation of interleukin-4 production; negative regulation of mast cell differentiation; negative regulation of protein binding; negative regulation of transcription by RNA polymerase II; outflow tract morphogenesis; platelet formation; positive regulation of transcription by RNA polymerase II; positive regulation of type II interferon production; primitive erythrocyte differentiation; regulation of chemokine production; regulation of definitive erythrocyte differentiation; regulation of transcription by RNA polymerase II; tricuspid valve formation; ventricular septum morphogenesis
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Reference #:
O35615
(UniProtKB)
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Alt. Names/Synonyms: Fog; FOG-1; Fog1; Friend of GATA 1; Friend of GATA protein 1; Friend of GATA-1; Zfpm1; Zinc finger protein multitype 1; Zinc finger protein ZFPM1; zinc finger protein, multitype 1
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Gene Symbols: Zfpm1
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Molecular weight:
105,984 Da
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Basal Isoelectric point:
6.45
Predict pI for various phosphorylation states
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