IL28RA The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Belongs to the type II cytokine receptor family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4|4 D3
Cellular Component:  integral component of membrane; interleukin-28 receptor complex; membrane; plasma membrane
Molecular Function:  cytokine receptor activity
Biological Process:  cytokine-mediated signaling pathway; defense response to virus; mucosal immune response; regulation of defense response to virus by host
Reference #:  Q8CGK5 (UniProtKB)
Alt. Names/Synonyms: class II cytokine receptor 12; CRF2-1; CRF2-12; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; I28RA; IFN-lambda R1; Ifnlr1; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Il28ra; INLR1; Interferon lambda receptor 1; interferon-lambda receptor 1; interleukin 28 receptor alpha; Interleukin-28 receptor subunit alpha; OTTMUSP00000010256
Gene Symbols: Il28ra
Molecular weight: 59,976 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene