HDAC9 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 7p21.1
Cellular Component:  cytoplasm; histone deacetylase complex; histone methyltransferase complex; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  histone deacetylase activity; histone deacetylase activity (H4-K16 specific); histone deacetylase binding; metal ion binding; NAD-dependent histone deacetylase activity (H3-K14 specific); protein binding; protein deacetylase activity; protein kinase C binding; repressing transcription factor binding; transcription corepressor activity; transcription factor binding
Biological Process:  B cell activation; B cell differentiation; cellular response to insulin stimulus; cholesterol homeostasis; heart development; histone deacetylation; histone H3 deacetylation; histone H4 deacetylation; histone H4-K16 deacetylation; inflammatory response; negative regulation of cytokine secretion; negative regulation of lipoprotein lipase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron differentiation; peptidyl-lysine deacetylation; positive regulation of cell migration involved in sprouting angiogenesis; regulation of skeletal muscle fiber development; regulation of striated muscle cell differentiation; response to amphetamine
Reference #:  Q9UKV0 (UniProtKB)
Alt. Names/Synonyms: DKFZp779K1053; HD7; HD7b; HD9; HDAC; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4/5-related protein; histone deacetylase 7; Histone deacetylase 7B; Histone deacetylase 9; Histone deacetylase-related protein; KIAA0744; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; MITR
Gene Symbols: HDAC9
Molecular weight: 111,297 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  Notch Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
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HDAC9

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein