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PTPRK
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine |
| Chromosomal Location of mouse Ortholog: 10 A4|10 15.06 cM |
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Cellular Component:
axon; cell junction; cell surface; cell-cell junction; dendrite; intracellular membrane-bounded organelle; leading edge membrane; membrane; neuronal cell body; photoreceptor outer segment; plasma membrane
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Molecular Function:
beta-catenin binding; gamma-catenin binding; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein kinase binding; protein tyrosine phosphatase activity
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Biological Process:
cell adhesion; cell migration; cellular response to reactive oxygen species; cellular response to UV; dephosphorylation; focal adhesion assembly; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of keratinocyte proliferation; neuron projection development; protein dephosphorylation; protein localization to cell surface; signal transduction; transforming growth factor beta receptor signaling pathway
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Reference #:
P35822
(UniProtKB)
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Alt. Names/Synonyms: AI853699; protein tyrosine phosphatase, receptor type, K; Protein-tyrosine phosphatase kappa; Ptpk; Ptprk; R-PTP-kappa; Receptor-type tyrosine-protein phosphatase kappa; RPTPkappa
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Gene Symbols: Ptprk
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Molecular weight:
164,186 Da
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Basal Isoelectric point:
5.61
Predict pI for various phosphorylation states
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