PTPRK Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of mouse Ortholog: 10 A4|10 15.06 cM
Cellular Component:  axon; cell junction; cell surface; cell-cell junction; dendrite; intracellular membrane-bounded organelle; leading edge membrane; membrane; neuronal cell body; photoreceptor outer segment; plasma membrane
Molecular Function:  beta-catenin binding; gamma-catenin binding; hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein kinase binding; protein tyrosine phosphatase activity
Biological Process:  cell adhesion; cell migration; cellular response to reactive oxygen species; cellular response to UV; dephosphorylation; focal adhesion assembly; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of keratinocyte proliferation; neuron projection development; protein dephosphorylation; protein localization to cell surface; signal transduction; transforming growth factor beta receptor signaling pathway
Reference #:  P35822 (UniProtKB)
Alt. Names/Synonyms: AI853699; protein tyrosine phosphatase, receptor type, K; Protein-tyrosine phosphatase kappa; Ptpk; Ptprk; R-PTP-kappa; Receptor-type tyrosine-protein phosphatase kappa; RPTPkappa
Gene Symbols: Ptprk
Molecular weight: 164,186 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein