PGM5 Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity. Belongs to the phosphohexose mutase family. Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 19|19 B
Cellular Component:  adherens junction; anchoring junction; cell-substrate junction; costamere; cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; dystrophin-associated glycoprotein complex; focal adhesion; intercalated disc; membrane; plasma membrane; sarcolemma; spot adherens junction; stress fiber; Z disc
Molecular Function:  intramolecular transferase activity, phosphotransferases; magnesium ion binding; phosphoglucomutase activity; protein binding
Biological Process:  carbohydrate metabolic process; cell adhesion; myofibril assembly; organic substance metabolic process; striated muscle tissue development
Reference #:  Q8BZF8 (UniProtKB)
Alt. Names/Synonyms: 4833423B07; 9530034F03Rik; aci; aciculin; D830025G17; Pgm5; phosphoglucomutase 5; Phosphoglucomutase-like protein 5
Gene Symbols: Pgm5
Molecular weight: 62,220 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein