PDIA6 May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. Expressed in platelets (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Isomerase
Chromosomal Location of mouse Ortholog: 12|12 A1.1
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; extracellular space; membrane; plasma membrane; smooth endoplasmic reticulum
Molecular Function:  isomerase activity; nuclease inhibitor activity; protein disulfide isomerase activity; protein-disulfide reductase activity
Biological Process:  negative regulation of IRE1-mediated unfolded protein response; response to endoplasmic reticulum stress
Reference #:  Q922R8 (UniProtKB)
Alt. Names/Synonyms: 1700015E05Rik; AL023058; C77895; CaB; CaBP5; OTTMUSP00000028252; P5; Pdia6; protein disulfide isomerase associated 6; protein disulfide isomerase-related protein; Protein disulfide-isomerase A6; thioredoxin domain containing 7; Thioredoxin domain-containing protein 7; Txndc; Txndc7
Gene Symbols: Pdia6
Molecular weight: 48,100 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene