CHD-4 Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Belongs to the SNF2/RAD54 helicase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.4.12; Helicase
Chromosomal Location of Human Ortholog: 6 F2|6 59.28 cM
Cellular Component:  centrosome; cytoplasm; cytoskeleton; nucleoplasm; nucleus; NuRD complex; protein-containing complex; protein-DNA complex
Molecular Function:  ATP binding; DNA binding; helicase activity; histone deacetylase binding; hydrolase activity; metal ion binding; nucleotide binding; protein binding; RNA polymerase II repressing transcription factor binding; transcription factor binding
Biological Process:  chromatin organization; negative regulation of transcription by RNA polymerase II; terminal button organization
Reference #:  Q6PDQ2 (UniProtKB)
Alt. Names/Synonyms: 9530019N15Rik; AA617397; BC005710; CHD-4; Chd4; chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; D6Ertd380e; KIAA4075; MGC11769; Mi-2 beta; Mi-2beta; mKIAA4075; OTTMUSP00000028311
Gene Symbols: Chd4
Molecular weight: 217,751 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CHD-4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene