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CHD-4
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Belongs to the SNF2/RAD54 helicase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; EC 3.6.4.12; Helicase |
| Chromosomal Location of mouse Ortholog: 6 F2|6 59.28 cM |
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Cellular Component:
centrosome; cerebellar granule cell to Purkinje cell synapse; chromatin; chromosome, telomeric region; cytoplasm; cytoskeleton; nucleoplasm; nucleus; NuRD complex; protein-containing complex; protein-DNA complex; RNA polymerase II transcription regulator complex; site of DNA damage
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Molecular Function:
ATP binding; ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; chromatin binding; DNA binding; DNA-binding transcription factor binding; helicase activity; histone binding; histone deacetylase binding; hydrolase activity; metal ion binding; nucleotide binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription coregulator binding; transcription corepressor activity; transcription factor binding
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Biological Process:
chromatin organization; chromatin remodeling; double-strand break repair via homologous recombination; histone deacetylation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; regulation of cell fate specification; regulation of stem cell differentiation; regulation of synapse assembly; terminal button organization
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Reference #:
Q6PDQ2
(UniProtKB)
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Alt. Names/Synonyms: 9530019N15Rik; AA617397; BC005710; CHD-4; Chd4; chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; D6Ertd380; D6Ertd380e; KIAA4075; MGC11769; Mi-2 beta; Mi-2be; Mi-2beta; mKIAA4075; OTTMUSP00000028311
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Gene Symbols: Chd4
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Molecular weight:
217,751 Da
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Basal Isoelectric point:
5.58
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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