HDAC5 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Coimmunoprecipitates only with HDAC3 family members. Interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; nuclear speck; nucleoplasm; nucleus
Molecular Function:  chromatin binding; histone deacetylase activity; histone deacetylase binding; metal ion binding; NAD-dependent histone deacetylase activity (H3-K14 specific); protein binding; protein deacetylase activity; protein kinase C binding; repressing transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; transcription factor binding
Biological Process:  B cell activation; B cell differentiation; cellular response to insulin stimulus; cellular response to lipopolysaccharide; chromatin organization; chromatin remodeling; chromatin silencing; histone deacetylation; histone H3 deacetylation; inflammatory response; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of myotube differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron differentiation; positive regulation of DNA-binding transcription factor activity; positive regulation of transcription by RNA polymerase II; protein deacetylation; regulation of gene expression, epigenetic; regulation of myotube differentiation; regulation of protein binding; response to activity; response to cocaine
Reference #:  Q9UQL6 (UniProtKB)
Alt. Names/Synonyms: Antigen NY-CO-9; FLJ90614; HD5; HDAC5; Histone deacetylase 5; KIAA0600; NY-CO-9
Gene Symbols: HDAC5
Molecular weight: 121,978 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein