NFE2L1 Activates erythroid-specific, globin gene expression. Interacts with KEAP1. Belongs to the bZIP family. CNC subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11 D|11 60.12 cM
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane; nucleus; protein-containing complex
Molecular Function:  cholesterol binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; lipid binding; promoter-specific chromatin binding; protein binding; protein domain specific binding; protein-containing complex binding; RNA polymerase II distal enhancer sequence-specific DNA binding; transcription coactivator activity; transcription regulatory region sequence-specific DNA binding
Biological Process:  cellular homeostasis; cellular response to cholesterol; cellular response to cold; cellular response to oxidative stress; cholesterol homeostasis; cholesterol metabolic process; cysteine transport; erythrocyte differentiation; fructose 6-phosphate metabolic process; glial cell fate commitment; glucose 6-phosphate metabolic process; glutathione metabolic process; lipid metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein polyubiquitination; regulation of fatty acid metabolic process; regulation of gene expression; regulation of glucose metabolic process; regulation of inflammatory response; regulation of lipid metabolic process; regulation of mitotic nuclear division; regulation of nucleus organization; regulation of proteasomal protein catabolic process; regulation of response to endoplasmic reticulum stress; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to copper ion; regulation of transcription, DNA-templated; response to endoplasmic reticulum stress; spinal cord motor neuron differentiation; steroid metabolic process
Reference #:  Q61985 (UniProtKB)
Alt. Names/Synonyms: AA408798; AW212678; Endoplasmic reticulum membrane sensor NFE2L1; LCR-F1; Lcrf1; NF-E2-related factor 1; NF2L1; NFE2-related factor 1; Nfe2l1; Nrf1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1; nuclear factor, erythroid derived 2,-like 1; OTTMUSP00000001551; OTTMUSP00000001552; TCF-11; TCF11
Gene Symbols: Nfe2l1
Molecular weight: 81,575 Da
Basal Isoelectric point: 4.58  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene