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POLA2
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Belongs to the DNA polymerase alpha subunit B family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine |
| Chromosomal Location of mouse Ortholog: 19|19 A |
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Cellular Component:
alpha DNA polymerase:primase complex; cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-directed DNA polymerase activity; protein binding
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Biological Process:
DNA replication; DNA replication initiation; DNA replication, synthesis of RNA primer; protein import into nucleus
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Reference #:
P33611
(UniProtKB)
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Alt. Names/Synonyms: AI573378; DNA polymerase alpha 2, 68 kDa; DNA polymerase alpha 70 kDa subunit; DNA polymerase alpha subunit B; DPOA2; Pola2; polymerase (DNA directed), alpha 2
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Gene Symbols: Pola2
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Molecular weight:
66,214 Da
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Basal Isoelectric point:
5.22
Predict pI for various phosphorylation states
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