POLA2 May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Belongs to the DNA polymerase alpha subunit B family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Chromosomal Location of mouse Ortholog: 19|19 A
Cellular Component:  alpha DNA polymerase:primase complex; cytosol; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-directed DNA polymerase activity; protein binding; protein heterodimerization activity
Biological Process:  DNA replication; DNA replication initiation; protein import into nucleus
Reference #:  P33611 (UniProtKB)
Alt. Names/Synonyms: AI573378; DNA polymerase alpha 2, 68 kDa; DNA polymerase alpha 70 kDa subunit; DNA polymerase alpha subunit B; DPOA2; Pola2; polymerase (DNA directed), alpha 2
Gene Symbols: Pola2
Molecular weight: 66,214 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene