SQSTM1 Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Promotes relocalization of 'Lys-63'-linked ubiquitinated TMEM173/STING to autophagosomes. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11|11 B1.3
Cellular Component:  aggresome; amphisome; autolysosome; autophagosome; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endosome; inclusion body; intracellular membrane-bounded organelle; Lewy body; lysosome; mitochondrion; nucleus; P-body; phagophore assembly site; PML body; sperm midpiece
Molecular Function:  enzyme binding; identical protein binding; ionotropic glutamate receptor binding; K63-linked polyubiquitin modification-dependent protein binding; metal ion binding; protein binding; protein homodimerization activity; protein kinase binding; protein kinase C binding; SH2 domain binding; transcription coregulator activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  aggrephagy; apoptotic process; autophagy; cell differentiation; endosome organization; immune system process; macroautophagy; mitochondrion organization; mitophagy; negative regulation of growth of symbiont in host; negative regulation of transcription by RNA polymerase II; positive regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; positive regulation of protein phosphorylation; protein heterooligomerization; protein localization to perinuclear region of cytoplasm; regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein complex stability; response to mitochondrial depolarisation; selective autophagy
Reference #:  Q64337 (UniProtKB)
Alt. Names/Synonyms: A170; OSF-6; Osi; OTTMUSP00000005736; oxidative stress induced; p62; RP23-319B15.3; sequestosome 1; Sequestosome-1; SQSTM; Sqstm1; STAP; STONE14; Ubiquitin-binding protein p62
Gene Symbols: Sqstm1
Molecular weight: 48,163 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SQSTM1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA