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CAF-1A
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. Belongs to the CHAF1A family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication |
| Chromosomal Location of mouse Ortholog: 17|17 D |
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Cellular Component:
CAF-1 complex; chromatin; nucleus; protein-containing complex
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Molecular Function:
chromo shadow domain binding; identical protein binding; protein binding
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Biological Process:
cell cycle; DNA damage response; DNA repair; DNA replication; DNA replication-dependent chromatin assembly; nucleosome assembly
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Reference #:
Q9QWF0
(UniProtKB)
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Alt. Names/Synonyms: AL023013; AL024058; Cac1p; CAF-; CAF-1; CAF-1 subunit A; CAF-1A; CAF-I 150 kDa subunit; CAF-I p150; CAF-Ip150; CAF1A; Caip150; Chaf1a; Chromatin assembly factor 1 subunit A; chromatin assembly factor 1, subunit A (p150); Chromatin assembly factor I p150 subunit
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Gene Symbols: Chaf1a
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Molecular weight:
101,936 Da
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Basal Isoelectric point:
5.28
Predict pI for various phosphorylation states
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