CAF-1A Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. Belongs to the CHAF1A family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 17|17 D
Cellular Component:  CAF-1 complex; nuclear chromatin; nucleus; protein-containing complex
Molecular Function:  chromo shadow domain binding; identical protein binding; protein binding
Biological Process:  cell cycle; cellular response to DNA damage stimulus; chromatin assembly; DNA repair; DNA replication; DNA replication-dependent nucleosome assembly; nucleosome assembly
Reference #:  Q9QWF0 (UniProtKB)
Alt. Names/Synonyms: AL023013; AL024058; Cac1p; CAF-; CAF-1; CAF-1 subunit A; CAF-1A; CAF-I 150 kDa subunit; CAF-I p150; CAF-Ip150; CAF1A; Caip150; Chaf1a; Chromatin assembly factor 1 subunit A; chromatin assembly factor 1, subunit A (p150); Chromatin assembly factor I p150 subunit
Gene Symbols: Chaf1a
Molecular weight: 101,936 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Select Structure to View Below

CAF-1A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene