CDC16 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20. Belongs to the APC6/CDC16 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 8|8 A1.1
Cellular Component:  anaphase-promoting complex; centrosome; cytoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  cell cycle; cell division; protein K11-linked ubiquitination
Reference #:  Q8R349 (UniProtKB)
Alt. Names/Synonyms: 2700071J12Rik; 2810431D22Rik; Anapc6; Anaphase-promoting complex subunit 6; APC6; Cdc16; CDC16 cell division cycle 16 homolog (S. cerevisiae); Cell division cycle protein 16 homolog; Cyclosome subunit 6
Gene Symbols: Cdc16
Molecular weight: 71,460 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC16

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene