HDAC4 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1. Belongs to the histone deacetylase family. HD type 2 subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  chromatin; cytoplasm; cytosol; histone deacetylase complex; nuclear speck; nucleoplasm; nucleus; transcription repressor complex
Molecular Function:  DNA-binding transcription factor binding; histone deacetylase activity; histone deacetylase binding; identical protein binding; molecular adaptor activity; potassium ion binding; protein binding; protein lysine deacetylase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; SUMO transferase activity; transcription cis-regulatory region binding; zinc ion binding
Biological Process:  B cell activation; B cell differentiation; cardiac muscle hypertrophy in response to stress; chromatin remodeling; epigenetic regulation of gene expression; histone deacetylation; histone H3 deacetylation; histone H4 deacetylation; inflammatory response; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of glycolytic process; negative regulation of myotube differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; peptidyl-lysine deacetylation; positive regulation of cell population proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of protein sumoylation; positive regulation of transcription by RNA polymerase II; protein deacetylation; protein sumoylation; regulation of protein binding; response to denervation involved in regulation of muscle adaptation; response to interleukin-1; type I interferon-mediated signaling pathway
Disease: Chromosome 2q37 Deletion Syndrome; Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies
Reference #:  P56524 (UniProtKB)
Alt. Names/Synonyms: AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; Histone deacetylase 4; histone deacetylase A; KIAA0288
Gene Symbols: HDAC4
Molecular weight: 119,040 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein