EPX Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Belongs to the peroxidase family. XPO subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Oxidoreductase
Chromosomal Location of human Ortholog: 17q22
Cellular Component:  extracellular region; extracellular space; secretory granule lumen
Molecular Function:  heme binding; lactoperoxidase activity; metal ion binding; peroxidase activity
Biological Process:  cellular oxidant detoxification; defense response to bacterium; defense response to nematode; eosinophil migration; hydrogen peroxide catabolic process; negative regulation of interleukin-10 production; negative regulation of interleukin-5 production; negative regulation of macrophage cytokine production; positive regulation of interleukin-4 production; response to oxidative stress
Disease: Eosinophil Peroxidase Deficiency
Reference #:  P11678 (UniProtKB)
Alt. Names/Synonyms: Eosinophil peroxidase; Eosinophil peroxidase heavy chain; Eosinophil peroxidase light chain; EPER; EPO; EPP; EPX; EPX-PEN; EPXD; PERE
Gene Symbols: EPX
Molecular weight: 81,040 Da
Basal Isoelectric point: 10.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene