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EPX
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Belongs to the peroxidase family. XPO subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.11.1.7; Oxidoreductase |
| Chromosomal Location of human Ortholog: 17q22 |
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Cellular Component:
extracellular region; extracellular space; secretory granule lumen
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Molecular Function:
heme binding; lactoperoxidase activity; metal ion binding; peroxidase activity
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Biological Process:
cellular oxidant detoxification; defense response to bacterium; defense response to nematode; eosinophil migration; hydrogen peroxide catabolic process; negative regulation of interleukin-10 production; negative regulation of interleukin-5 production; negative regulation of macrophage cytokine production; positive regulation of interleukin-4 production; response to oxidative stress
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Disease: Eosinophil Peroxidase Deficiency
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Reference #:
P11678
(UniProtKB)
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Alt. Names/Synonyms: Eosinophil peroxidase; Eosinophil peroxidase heavy chain; Eosinophil peroxidase light chain; EPER; EPO; EPP; EPX; EPX-PEN; EPXD; PERE
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Gene Symbols: EPX
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Molecular weight:
81,040 Da
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Basal Isoelectric point:
10.31
Predict pI for various phosphorylation states
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