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SPAG1
May play a role in the cytoplasmic assembly of the ciliary dynein arms. May play a role in fertilization. Binds GTP and has GTPase activity. Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cancer Testis Antigen (CTA); Microtubule-binding |
| Chromosomal Location of mouse Ortholog: 15|15 B3.1 |
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Cellular Component:
cytoplasm; cytosol; protein folding chaperone complex
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Molecular Function:
GTP binding; hydrolase activity; nucleotide binding
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Biological Process:
axonemal dynein complex assembly; single fertilization
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Reference #:
Q80ZX8
(UniProtKB)
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Alt. Names/Synonyms: CT140; Infertility-related sperm protein Spag-1; Spag1; sperm associated antigen 1; Sperm-associated antigen 1; TPIS; TPR-containing protein involved in spermatogenesis
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Gene Symbols: Spag1
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Molecular weight:
100,670 Da
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Basal Isoelectric point:
5.46
Predict pI for various phosphorylation states
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