HRC1 Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of mouse Ortholog: 7|7 F5
Cellular Component:  cytoplasm; cytoskeleton; microtubule organizing center
Biological Process:  apoptotic process; regulation of microtubule cytoskeleton organization; signal transduction
Reference #:  Q9DD19 (UniProtKB)
Alt. Names/Synonyms: 2400009B11Rik; AW210608; HRC1; OTTMUSP00000026946; Ras association (RalGDS/AF-6) domain family (N-terminal) member 7; Ras association (RalGDS/AF-6) domain family 7; Ras association domain-containing protein 7; RASF7; Rassf7
Gene Symbols: Rassf7
Molecular weight: 39,247 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene