PAP-alpha Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. Belongs to the poly(A) polymerase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; RNA processing; RNA splicing; Transferase
Chromosomal Location of mouse Ortholog: 12|12 E
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  ATP binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; polynucleotide adenylyltransferase activity; protein binding; RNA binding; transferase activity
Biological Process:  mRNA polyadenylation; mRNA processing; regulation of mRNA 3'-end processing; RNA 3'-end processing; RNA polyadenylation
Reference #:  Q61183 (UniProtKB)
Alt. Names/Synonyms: Pap; PAP-alpha; PapIII; PAPOA; Papola; Plap; poly (A) polymerase alpha; Poly(A) polymerase alpha; Polynucleotide adenylyltransferase
Gene Symbols: Papola
Molecular weight: 82,309 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene