PAP-alpha
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. Belongs to the poly(A) polymerase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.7.19; RNA processing; RNA splicing; Transferase |
Chromosomal Location of mouse Ortholog: 12|12 E |
Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
ATP binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; poly(A) RNA polymerase activity; protein binding; RNA binding; transferase activity
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Biological Process:
cytoplasmic polyadenylation; mRNA polyadenylation; mRNA processing; regulation of mRNA 3'-end processing; RNA 3'-end processing
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Reference #:
Q61183
(UniProtKB)
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Alt. Names/Synonyms: Pap; PAP-alpha; PapIII; PAPOA; Papola; Plap; poly (A) polymerase alpha; Poly(A) polymerase alpha; Polynucleotide adenylyltransferase
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Gene Symbols: Papola
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Molecular weight:
82,309 Da
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Basal Isoelectric point:
6.94
Predict pI for various phosphorylation states
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