HNMT Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Belongs to the methyltransferase superfamily. HNMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; EC 2.1.1.8; Methyltransferase
Chromosomal Location of Human Ortholog: 2|2 A3
Cellular Component:  cytoplasm; neuron projection
Molecular Function:  histamine N-methyltransferase activity; methyltransferase activity; N-methyltransferase activity; transferase activity
Biological Process:  brain development; histamine catabolic process; methylation; regulation of neurotransmitter levels
Reference #:  Q91VF2 (UniProtKB)
Alt. Names/Synonyms: 1500031F01Rik; AI788969; Histamine N-methyltransferase; HMT; Hnmt; OTTMUSP00000012588; OTTMUSP00000012589; OTTMUSP00000012590
Gene Symbols: Hnmt
Molecular weight: 33,665 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
Select Structure to View Below

HNMT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene