eIF2B-beta Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Belongs to the eIF-2B alpha/beta/delta subunits family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; GEF; GEF, misc.; RNA-binding; Translation
Chromosomal Location of mouse Ortholog: 12|12 D1
Cellular Component:  axon; cytoplasm; endoplasmic reticulum; eukaryotic translation initiation factor 2B complex; glycinergic synapse; postsynapse
Molecular Function:  ATP binding; GTP binding; guanyl-nucleotide exchange factor activity; translation initiation factor activity
Biological Process:  cellular metabolic process; central nervous system development; myelination; oligodendrocyte development; ovarian follicle development; positive regulation of axon extension; response to glucose; response to heat; response to peptide hormone; T cell receptor signaling pathway; translation; translational initiation
Reference #:  Q99LD9 (UniProtKB)
Alt. Names/Synonyms: AA409345; C85417; EI2BB; eIF-2B GDP-GTP exchange factor subunit beta; EIF-2Bbe; EIF-2Bbeta; EIF2; EIF2B; eIF2B-beta; Eif2b2; eukaryotic translation initiation factor 2B, subunit 2 beta; Translation initiation factor eIF-2B subunit beta
Gene Symbols: Eif2b2
Molecular weight: 38,898 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein