H4 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H4 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.2
Cellular Component:  extracellular region; nuclear chromosome; nuclear nucleosome; nucleoplasm; nucleosome; nucleus; protein-containing complex
Molecular Function:  DNA binding; protein binding; protein domain specific binding; protein heterodimerization activity
Biological Process:  cellular protein metabolic process; CENP-A containing nucleosome assembly; chromatin silencing at rDNA; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; DNA-templated transcription, initiation; double-strand break repair via nonhomologous end joining; negative regulation of gene expression, epigenetic; negative regulation of megakaryocyte differentiation; nucleosome assembly; protein heterotetramerization; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; telomere capping; telomere organization
Reference #:  P62805 (UniProtKB)
Alt. Names/Synonyms: H4; H4 clustered histone 1; H4 histone family, member A; H4-16; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4; histone 1, H4a; histone cluster 1 H4 family member a; histone cluster 1, H4a; Histone H4
Gene Symbols: HIST1H4A
Molecular weight: 11,236 Da
Basal Isoelectric point: 11.36  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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