FNTB Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Belongs to the protein prenyltransferase subunit beta family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.5.1.58; Transferase
Chromosomal Location of Human Ortholog: 12 C3|12 33.73 cM
Cellular Component:  microtubule associated complex; protein farnesyltransferase complex; protein-containing complex
Molecular Function:  catalytic activity; farnesyltranstransferase activity; metal ion binding; prenyltransferase activity; protein farnesyltransferase activity; transferase activity; zinc ion binding
Biological Process:  negative regulation of cell proliferation; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; positive regulation of nitric-oxide synthase biosynthetic process; protein farnesylation; protein prenylation; regulation of fibroblast proliferation; response to cytokine; response to inorganic substance; response to organic cyclic compound; wound healing
Reference #:  Q8K2I1 (UniProtKB)
Alt. Names/Synonyms: 2010013E13Rik; AA409500; CAAX farnesyltransferase subunit beta; farnesyltransferase, CAAX box, beta; Fntb; FTase-beta; Protein farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta
Gene Symbols: Fntb
Molecular weight: 48,820 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below

FNTB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene