|
MGMT
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. Note: This description may include information from UniProtKB.
|
| Protein type: Apoptosis; DNA repair, damage; EC 2.1.1.63; Methyltransferase; Nuclear receptor co-regulator |
| Chromosomal Location of Human Ortholog: 7 F3|7 82.07 cM |
|
Cellular Component:
nucleoplasm; nucleus
|
|
Molecular Function:
calcium ion binding; catalytic activity; DNA binding; metal ion binding; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity; transferase activity
|
|
Biological Process:
cellular response to DNA damage stimulus; DNA dealkylation involved in DNA repair; DNA repair; methylation; negative regulation of apoptotic process; negative regulation of cell death; positive regulation of DNA repair; positive regulation of double-strand break repair; regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
|
Reference #:
P26187
(UniProtKB)
|
|
Alt. Names/Synonyms: 6-O-methylguanine-DNA methyltransferase; Agat; AGT; AI267024; Methylated-DNA--protein-cysteine methyltransferase; MGC107020; MGMT; O-6-alkylguanine-DNA alkyltransferase; O-6-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase
|
|
Gene Symbols: Mgmt
|
|
Molecular weight:
22,435 Da
|
|
Basal Isoelectric point:
7.72
Predict pI for various phosphorylation states
|
