MGMT Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; DNA repair, damage; EC; Methyltransferase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 7 F3|7 82.07 cM
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  calcium ion binding; catalytic activity; DNA binding; metal ion binding; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity; transferase activity
Biological Process:  cellular response to DNA damage stimulus; DNA dealkylation involved in DNA repair; DNA repair; methylation; negative regulation of apoptotic process; negative regulation of cell death; positive regulation of DNA repair; positive regulation of double-strand break repair; regulation of cysteine-type endopeptidase activity involved in apoptotic process
Reference #:  P26187 (UniProtKB)
Alt. Names/Synonyms: 6-O-methylguanine-DNA methyltransferase; Agat; AGT; AI267024; Methylated-DNA--protein-cysteine methyltransferase; MGC107020; MGMT; O-6-alkylguanine-DNA alkyltransferase; O-6-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase
Gene Symbols: Mgmt
Molecular weight: 22,435 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA