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osteopontin
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. Belongs to the osteopontin family. Bone. Found in plasma. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 5 E5|5 50.68 cM |
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Cellular Component:
apical part of cell; cell projection; cytoplasm; extracellular region; extracellular space; Golgi apparatus; perinuclear region of cytoplasm; vesicle
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Molecular Function:
cytokine activity; extracellular matrix binding; integrin binding; ion binding; small molecule binding
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Biological Process:
androgen catabolic process; biomineral tissue development; bone mineralization; calcium ion homeostasis; cell adhesion; cellular response to fluid shear stress; cellular response to leukemia inhibitory factor; cellular response to testosterone stimulus; collecting duct development; intracellular calcium ion homeostasis; intracellular chloride ion homeostasis; intracellular phosphate ion homeostasis; intracellular sodium ion homeostasis; negative regulation of apoptotic process; neutrophil chemotaxis; ossification; osteoblast differentiation; positive regulation of bone resorption; positive regulation of cell-substrate adhesion; positive regulation of DNA-templated transcription; positive regulation of estradiol secretion; response to organic substance; response to steroid hormone; response to vitamin D; urate biosynthetic process
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Reference #:
P10923
(UniProtKB)
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Alt. Names/Synonyms: 2AR; 44 kDa bone phosphoprotein; AA960535; AI790405; Apl-1; BNSP; Bone sialoprotein 1; Bsp; BSPI; Calcium oxalate crystal growth inhibitor protein; Early T-lymphocyte activation 1 protein; Eta; ETA-; Eta-1; Minopontin; Op; Opn; Opnl; ost; Osteopontin; osteopontin-like protein; OSTP; OTTMUSP00000029095; OTTMUSP00000029097; OTTMUSP00000029098; Ric; Secreted phosphoprotein 1; SPP-1; Spp1
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Gene Symbols: Spp1
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Molecular weight:
32,459 Da
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Basal Isoelectric point:
4.34
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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