APOB Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Note: This description may include information from UniProtKB.
Protein type: Carrier; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12 A1.1|12 3.53 cM
Cellular Component:  chylomicron; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum exit site; extracellular region; extracellular space; high-density lipoprotein particle; intermediate-density lipoprotein particle; intracellular membrane-bounded organelle; low-density lipoprotein particle; mature chylomicron; neuronal cell body; very-low-density lipoprotein particle; vesicle lumen; vesicle membrane
Molecular Function:  cholesterol transporter activity; heparin binding; lipase binding; lipid transporter activity; low-density lipoprotein particle receptor binding; phospholipid binding; signaling receptor binding
Biological Process:  artery morphogenesis; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; fertilization; flagellated sperm motility; in utero embryonic development; lipid catabolic process; lipid metabolic process; lipid transport; lipoprotein biosynthetic process; lipoprotein catabolic process; lipoprotein metabolic process; lipoprotein transport; low-density lipoprotein particle clearance; low-density lipoprotein particle remodeling; nervous system development; positive regulation of cholesterol storage; positive regulation of gene expression; positive regulation of lipid storage; positive regulation of macrophage derived foam cell differentiation; post-embryonic development; regulation of cholesterol biosynthetic process; response to carbohydrate; spermatogenesis; steroid metabolic process; triglyceride catabolic process; triglyceride mobilization
Reference #:  E9Q414 (UniProtKB)
Alt. Names/Synonyms: AI315052; Apo B-100; Apo B-48; Apob; Apob protein; apob-; apob-100; apob-48; Apolipoprotein B; Apolipoprotein B-100; Apolipoprotein B-48; MGC176318
Gene Symbols: Apob
Molecular weight: 509,432 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Select Structure to View Below

APOB

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein