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CABYR
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium. Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Cancer Testis Antigen (CTA) |
| Chromosomal Location of mouse Ortholog: 18|18 A1 |
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Cellular Component:
cell projection; cilium; cytoplasm; cytoskeleton; cytosol; motile cilium; nucleoplasm; sperm end piece; sperm fibrous sheath; sperm principal piece
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Molecular Function:
calcium ion binding; enzyme binding; metal ion binding; protein binding; protein domain specific binding
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Biological Process:
calcium-mediated signaling; sperm capacitation
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Reference #:
Q9D424
(UniProtKB)
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Alt. Names/Synonyms: 1700016C01Rik; 4933421A18Rik; Cabyr; Calcium-binding protein 86; Calcium-binding tyrosine phosphorylation-regulated protein; calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); calcium-binding tyrosine-phosphorylation regulated protein, isoform 2; CBP8; Cbp86; CT88; FSP; FSP-2; MGC130217; MGC130218; Testis-specific calcium-binding protein CBP86
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Gene Symbols: Cabyr
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Molecular weight:
48,333 Da
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Basal Isoelectric point:
4.48
Predict pI for various phosphorylation states
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