SPRY1 May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Induced by FGF signaling. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3|3 B
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; membrane; nucleoplasm
Molecular Function:  protein binding
Biological Process:  bud elongation involved in lung branching; establishment of mitotic spindle orientation; metanephros development; multicellular organism development; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of GTPase activity; negative regulation of MAP kinase activity; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of Ras protein signal transduction; organ induction; regulation of signal transduction; ureteric bud development
Reference #:  Q9QXV9 (UniProtKB)
Alt. Names/Synonyms: inhibitor of receptor tyrosine kinases; OTTMUSP00000007984; OTTMUSP00000007985; OTTMUSP00000007986; Protein sprouty homolog 1; sprouty 1; sprouty homolog 1 (Drosophila); sprouty1; Spry-1; Spry1; SPY1
Gene Symbols: Spry1
Molecular weight: 34,004 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene