H3F3A Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 1q42.12
Cellular Component:  Barr body; extracellular region; nuclear chromosome; nuclear chromosome, telomeric region; nuclear nucleosome; nucleoplasm; nucleosome; nucleus; protein-containing complex
Molecular Function:  nucleosomal DNA binding; protein binding; protein heterodimerization activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding
Biological Process:  blood coagulation; cell proliferation; cellular protein metabolic process; chromatin silencing at rDNA; DNA replication-independent nucleosome assembly; embryo implantation; male gonad development; multicellular organism growth; muscle cell differentiation; negative regulation of chromosome condensation; negative regulation of gene expression, epigenetic; nucleosome assembly; nucleus organization; oogenesis; osteoblast differentiation; pericentric heterochromatin assembly; positive regulation of cell growth; regulation of centromere complex assembly; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; single fertilization; spermatid development; telomere organization; telomeric heterochromatin assembly
Disease: Bryant-li-bhoj Neurodevelopmental Syndrome 1
Reference #:  P84243 (UniProtKB)
Alt. Names/Synonyms: H3 histone family member 3A; H3 histone, family 3A; H3 histone, family 3B (H3.3B); H3-3A; H3-3B; H3.3 histone A; H3.3A; H3.3B; H33; H3F3; H3F3A; H3F3B; Histone H3.3
Gene Symbols: H3-3A
Molecular weight: 15,197 Da
Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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