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Bcl-11A
Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex. Repressor of fetal hemoglobin (HbF) level. Involved in brain development. Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 11|11 A3.2 |
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Cellular Component:
cytoplasm; nuclear body; nucleoplasm; nucleus; paraspeckles; postsynapse; SWI/SNF complex
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Molecular Function:
DNA-binding transcription factor activity; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coregulator activity; transcription corepressor activity; transcription regulatory region nucleic acid binding
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Biological Process:
B cell differentiation; DNA-templated transcription; gene expression; negative regulation of branching morphogenesis of a nerve; negative regulation of collateral sprouting; negative regulation of dendrite development; negative regulation of dendrite extension; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of neuron projection development; negative regulation of neuron remodeling; negative regulation of transcription by RNA polymerase II; positive regulation of collateral sprouting; positive regulation of gene expression; positive regulation of neuron projection development; protein sumoylation; regulation of dendrite development; regulation of transcription by RNA polymerase II; T cell differentiation
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Reference #:
Q9QYE3
(UniProtKB)
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Alt. Names/Synonyms: 2810047E18Rik; B cell CLL/lymphoma 11A (zinc finger protein); B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell lymphoma/leukemia 11A; BC11A; BCL-11A; Bcl11a; COUP-TF interacting protein 1; COUP-TF-interacting protein 1; CTI; Ctip1; D930021L15Rik; Ecotropic viral integration site 9 protein; Evi; EVI-9; Evi9; Evi9a; Evi9b; Evi9c; Kiaa1809; mKIAA1809; myeloid leukemia; OTTMUSP00000005476
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Gene Symbols: Bcl11a
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Molecular weight:
83,855 Da
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Basal Isoelectric point:
5.85
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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