KIF18B In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Shows a prominent expression in the amygdala. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of human Ortholog: 17q21.31
Cellular Component:  astral microtubule; cytoplasm; cytosol; kinesin complex; microtubule; microtubule end; microtubule plus-end; mitotic spindle astral microtubule; mitotic spindle midzone; nuclear body; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATP hydrolysis activity; cytoskeletal motor activity; kinesin binding; microtubule binding; microtubule motor activity; plus-end-directed microtubule motor activity; protein binding
Biological Process:  cell division; microtubule depolymerization; microtubule-based movement; mitotic cell cycle; mitotic sister chromatid segregation; regulation of cell division
Reference #:  Q86Y91 (UniProtKB)
Alt. Names/Synonyms: KI18B; KIF18B; kinesin family member 18B; Kinesin-like protein KIF18B
Gene Symbols: KIF18B
Molecular weight: 93,011 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene