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KIF18B
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Shows a prominent expression in the amygdala. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motor |
| Chromosomal Location of human Ortholog: 17q21.31 |
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Cellular Component:
astral microtubule; cytoplasm; cytosol; kinesin complex; microtubule end; microtubule plus-end; mitotic spindle astral microtubule; mitotic spindle midzone; nuclear body; nucleoplasm; nucleus
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Molecular Function:
ATP binding; ATP hydrolysis activity; cytoskeletal motor activity; kinesin binding; microtubule binding; plus-end-directed microtubule motor activity; protein binding
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Biological Process:
cell division; microtubule depolymerization; microtubule-based movement; mitotic cell cycle; mitotic sister chromatid segregation; regulation of cell division
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Reference #:
Q86Y91
(UniProtKB)
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Alt. Names/Synonyms: KI18B; KIF18B; kinesin family member 18B; Kinesin-like protein KIF18B
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Gene Symbols: KIF18B
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Molecular weight:
93,011 Da
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Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
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