PRAM1 May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component:  protein-containing complex
Molecular Function:  lipid binding; protein binding; protein kinase binding
Biological Process:  regulation of neutrophil degranulation
Reference #:  Q96QH2 (UniProtKB)
Alt. Names/Synonyms: MGC39864; PML-RAR; PML-RARA regulated adaptor molecule 1; PML-RARA target gene encoding an Adaptor Molecule-1; PML-RARA-regulated adapter molecule 1; PRAM; PRAM-1; PRAM1
Gene Symbols: PRAM1
Molecular weight: 79,245 Da
Basal Isoelectric point: 9.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene