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PRAM1
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 19p13.2 |
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Cellular Component:
plasma membrane; protein-containing complex
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Molecular Function:
lipid binding; protein binding; protein kinase binding
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Biological Process:
integrin-mediated signaling pathway; protein localization to plasma membrane; regulation of neutrophil degranulation; T cell receptor signaling pathway
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Reference #:
Q96QH2
(UniProtKB)
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Alt. Names/Synonyms: MGC39864; PML-RAR; PML-RARA regulated adaptor molecule 1; PML-RARA target gene encoding an Adaptor Molecule-1; PML-RARA-regulated adapter molecule 1; PRAM; PRAM-1; PRAM1
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Gene Symbols: PRAM1
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Molecular weight:
73,969 Da
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Basal Isoelectric point:
9.67
Predict pI for various phosphorylation states
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