VPS13D Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. Belongs to the VPS13 family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 1p36.22-p36.21
Cellular Component:  extrinsic component of membrane
Biological Process:  lipid transport; mitochondrion organization; positive regulation of mitophagy; protein retention in Golgi apparatus; protein targeting to vacuole
Disease: Spinocerebellar Ataxia, Autosomal Recessive 4
Reference #:  Q5THJ4 (UniProtKB)
Alt. Names/Synonyms: FLJ23066; Intermembrane lipid transfer protein VPS13D; KIAA0453; SCAR4; vacuolar protein sorting 13 homolog D; vacuolar protein sorting 13 homolog D (S. cerevisiae); vacuolar protein sorting 13D; Vacuolar protein sorting-associated protein 13D; VP13D; VPS13D
Gene Symbols: VPS13D
Molecular weight: 491,916 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein