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VPS13D
Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. Belongs to the VPS13 family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of human Ortholog: 1p36.22-p36.21 |
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Cellular Component:
extrinsic component of membrane
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Biological Process:
lipid transport; mitochondrion organization; positive regulation of mitophagy; protein retention in Golgi apparatus; protein targeting to vacuole
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Disease: Spinocerebellar Ataxia, Autosomal Recessive 4
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Reference #:
Q5THJ4
(UniProtKB)
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Alt. Names/Synonyms: FLJ23066; Intermembrane lipid transfer protein VPS13D; KIAA0453; SCAR4; vacuolar protein sorting 13 homolog D; vacuolar protein sorting 13 homolog D (S. cerevisiae); vacuolar protein sorting 13D; Vacuolar protein sorting-associated protein 13D; VP13D; VPS13D
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Gene Symbols: VPS13D
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Molecular weight:
491,916 Da
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Basal Isoelectric point:
6.15
Predict pI for various phosphorylation states
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