CABIN1 May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. Widely expressed in different tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Protein phosphatase, regulatory subunit; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component:  aggresome; cytosol; nucleoplasm
Molecular Function:  protein phosphatase inhibitor activity
Biological Process:  cell surface receptor signaling pathway; DNA replication-independent nucleosome assembly; negative regulation of phosphoprotein phosphatase activity
Reference #:  Q9Y6J0 (UniProtKB)
Alt. Names/Synonyms: CABIN; CABIN1; CAIN; calcineurin binding protein 1; calcineurin binding protein cabin 1; Calcineurin inhibitor; Calcineurin-binding protein cabin-1; KB-318B8.7; KIAA0330; PPP3IN
Gene Symbols: CABIN1
Molecular weight: 246,352 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein