RASGRF1 Promotes the exchange of Ras-bound GDP by GTP. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of mouse Ortholog: 9 E3.1|9 47.31 cM
Cellular Component:  apical dendrite; apicolateral plasma membrane; basolateral plasma membrane; cytoplasm; cytosol; growth cone; neuronal cell body
Molecular Function:  glutamate receptor binding; guanyl-nucleotide exchange factor activity; protein binding; protein C-terminus binding; protein kinase binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  activation of GTPase activity; cell proliferation; intracellular signal transduction; neuron projection development; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of Ras protein signal transduction; regulation of neuronal synaptic plasticity; regulation of NMDA receptor activity; regulation of Rac protein signal transduction; regulation of Ras protein signal transduction; regulation of Rho protein signal transduction; regulation of synaptic plasticity; response to endoplasmic reticulum stress; small GTPase mediated signal transduction
Reference #:  P27671 (UniProtKB)
Alt. Names/Synonyms: AI844718; Cdc25; CDC25Mm; GNRP; Grf; GRF beta; Grf1; Grfbe; Grfbeta; guanine nucleotide releasing factor 1; Guanine nucleotide-releasing protein; p190; P190-A; p190RhoGEF; Ras guanine release factor beta; RAS protein-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25; Rasgrf1; RGRF1
Gene Symbols: Rasgrf1
Molecular weight: 144,102 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene