KIR2DL1 Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. Expressed by NK cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  protein binding; signaling receptor activity
Biological Process:  immune response; natural killer cell inhibitory signaling pathway; regulation of immune response
Reference #:  P43626 (UniProtKB)
Alt. Names/Synonyms: CD158 antigen-like family member A; CD158A; KI2L1; Killer cell immunoglobulin-like receptor 2DL1; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; killer inhibitory receptor 2-2-1; KIR-K64; KIR221; KIR2DL1; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT; NKAT-1; NKAT1; p58 killer cell inhibitory receptor KIR-K64; p58 natural killer cell receptor clones CL-42/47.11; p58 NK cell inhibitory receptor NKR-K6; p58 NK receptor CL-42/47.11; p58.1; p58.1 MHC class-I-specific NK receptor
Gene Symbols: KIR2DL1
Molecular weight: 38,505 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
Select Structure to View Below

KIR2DL1

Protein Structure Not Found.


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