KIR2DL1 Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. Expressed by NK cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 19q13.42
Cellular Component:  plasma membrane
Molecular Function:  protein binding; signaling receptor activity
Biological Process:  immune response; natural killer cell inhibitory signaling pathway
Reference #:  P43626 (UniProtKB)
Alt. Names/Synonyms: CD158 antigen-like family member A; CD158A; KI2L1; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; Killer cell immunoglobulin-like receptor 2DL1; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; killer inhibitory receptor 2-2-1; KIR-K64; KIR221; KIR2DL protein; KIR2DL1; KIR2DL1/3DL2; KIR2DL3; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT; NKAT-1; NKAT1; p58 killer cell inhibitory receptor KIR-K64; p58 natural killer cell receptor clones CL-42/47.11; p58 NK cell inhibitory receptor NKR-K6; p58 NK receptor CL-42/47.11; p58.1; p58.1 MHC class-I-specific NK receptor
Gene Symbols: KIR2DL1
Molecular weight: 38,580 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein